Description
InformationAcelarin (NUC-1031) Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.TargetsDNA synthesis (Cell-free assay) 0.2 nM(EC50)In vitroNUC-1031 is a gemcitabine phosphoramidate prodrug with potent cytostatic activity in a range of different tumor cell lines. Importantly, compared with gemcitabine, NUC-1031 activation is significantly less dependent on deoxycytidine kinase and on nucleoside transporters, and it is resistant to cytidine deaminase-mediated degradation.In vivoNUC-1031 shows a significant reduction in tumor volumes in vivo in pancreatic cancer xenografts.Cell Research(from reference)Cell lines：Murine leukemia L1210, human lymphocyte CEM Concentrations：1 µM Incubation Time：1 h